SYLLA, Tahiri; POUYSEGU, Laurent; DA COSTA, Gregory; DEFFIEUX, Denis; MONTI, Jean-Pierre; QUIDEAU, Stéphane

doi:10.1002/anie.201411606

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SYLLA, Tahiri
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]

POUYSEGU, Laurent

Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]

DA COSTA, Gregory

Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

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Angewandte Chemie International Edition. 2015-07-06, vol. 54, n° 28, p. 8217-21

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The screening of natural products in the search for new lead compounds against Alzheimer's disease has unveiled several plant polyphenols that are capable of inhibiting the formation of toxic β-amyloid fibrils. Gallic acid based gallotannins are among these polyphenols, but their antifibrillogenic activity has thus far been examined using "tannic acid", a commercial mixture of gallotannins and other galloylated glucopyranoses. The first total syntheses of two true gallotannins, a hexagalloylglucopyranose and a decagalloylated compound whose structure is commonly used to depict "tannic acid", are now described. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid β-peptide (Aβ) aggregation in vitro, and monogalloylated α-glucogallin and a natural β-hexagalloylglucose are shown to be the strongest inhibitors.< Réduire

Mots clés en anglais

Alzheimer Disease

Amyloid beta-Peptides

Gallic Acid

Molecular Structure

Polyphenols

Tannins

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Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation.

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