Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation.
SYLLA, Tahiri
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
POUYSEGU, Laurent
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
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Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
SYLLA, Tahiri
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
POUYSEGU, Laurent
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
DEFFIEUX, Denis
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
QUIDEAU, Stéphane
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
< Reduce
Institut Européen de Chimie et Biologie [IECB]
Institut des Sciences Moléculaires [ISM]
Language
EN
Article de revue
This item was published in
Angewandte Chemie International Edition. 2015-07-06, vol. 54, n° 28, p. 8217-21
English Abstract
The screening of natural products in the search for new lead compounds against Alzheimer's disease has unveiled several plant polyphenols that are capable of inhibiting the formation of toxic β-amyloid fibrils. Gallic acid ...Read more >
The screening of natural products in the search for new lead compounds against Alzheimer's disease has unveiled several plant polyphenols that are capable of inhibiting the formation of toxic β-amyloid fibrils. Gallic acid based gallotannins are among these polyphenols, but their antifibrillogenic activity has thus far been examined using "tannic acid", a commercial mixture of gallotannins and other galloylated glucopyranoses. The first total syntheses of two true gallotannins, a hexagalloylglucopyranose and a decagalloylated compound whose structure is commonly used to depict "tannic acid", are now described. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid β-peptide (Aβ) aggregation in vitro, and monogalloylated α-glucogallin and a natural β-hexagalloylglucose are shown to be the strongest inhibitors.Read less <
English Keywords
Alzheimer Disease
Amyloid beta-Peptides
Gallic Acid
Molecular Structure
Polyphenols
Tannins
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