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Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation.

dc.rights.licenseopenen_US
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorSYLLA, Tahiri
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPOUYSEGU, Laurent
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorDA COSTA, Gregory
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDEFFIEUX, Denis
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMONTI, Jean-Pierre
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorQUIDEAU, Stéphane
dc.date.accessioned2021-05-21T16:11:48Z
dc.date.available2021-05-21T16:11:48Z
dc.date.issued2015-07-06
dc.identifier.issn1521-3773en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78602
dc.description.abstractEnThe screening of natural products in the search for new lead compounds against Alzheimer's disease has unveiled several plant polyphenols that are capable of inhibiting the formation of toxic β-amyloid fibrils. Gallic acid based gallotannins are among these polyphenols, but their antifibrillogenic activity has thus far been examined using "tannic acid", a commercial mixture of gallotannins and other galloylated glucopyranoses. The first total syntheses of two true gallotannins, a hexagalloylglucopyranose and a decagalloylated compound whose structure is commonly used to depict "tannic acid", are now described. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid β-peptide (Aβ) aggregation in vitro, and monogalloylated α-glucogallin and a natural β-hexagalloylglucose are shown to be the strongest inhibitors.
dc.language.isoENen_US
dc.subject.enAlzheimer Disease
dc.subject.enAmyloid beta-Peptides
dc.subject.enGallic Acid
dc.subject.enMolecular Structure
dc.subject.enPolyphenols
dc.subject.enTannins
dc.title.enGallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation.
dc.title.alternativeAngew Chem Int Ed Englen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/anie.201411606en_US
dc.identifier.pubmed26013280en_US
bordeaux.journalAngewandte Chemie International Editionen_US
bordeaux.page8217-21en_US
bordeaux.volume54en_US
bordeaux.hal.laboratoriesUnité de Recherche Oenologie - EA 4577en_US
bordeaux.issue28en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
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