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Fluid dynamics characterisation of a rotating bioreactor for tissue engineering
DROCHON, Agnes
Université de Technologie de Compiègne [UTC]
Centre National de la Recherche Scientifique [CNRS]
Biomécanique et Bioingénierie [BMBI]
Institut de Mécanique et d'Ingénierie [I2M]
Université de Technologie de Compiègne [UTC]
Centre National de la Recherche Scientifique [CNRS]
Biomécanique et Bioingénierie [BMBI]
Institut de Mécanique et d'Ingénierie [I2M]
DROCHON, Agnes
Université de Technologie de Compiègne [UTC]
Centre National de la Recherche Scientifique [CNRS]
Biomécanique et Bioingénierie [BMBI]
Institut de Mécanique et d'Ingénierie [I2M]
< Reduce
Université de Technologie de Compiègne [UTC]
Centre National de la Recherche Scientifique [CNRS]
Biomécanique et Bioingénierie [BMBI]
Institut de Mécanique et d'Ingénierie [I2M]
Language
EN
Article de revue
This item was published in
Medical Engineering & Physics. 2022-07-01, vol. 105
English Abstract
Biological scaffolds composed of extracellular matrix (ECM) derived from decellularised tissue are increasingly used in regenerative medicine. In this project, a flow perfusion bioreactor (the rotary cell culture system ...Read more >
Biological scaffolds composed of extracellular matrix (ECM) derived from decellularised tissue are increasingly used in regenerative medicine. In this project, a flow perfusion bioreactor (the rotary cell culture system (RCCS), commercially available from Synthecon (Houston, TX)) is used in order to obtain some esophageal extracellular matrix. A theoretical mechanical characterisation of this experimental set-up is provided. Due to the combination of rotation and perfusion, some spiral Poiseuille flow is created inside the tubular esophagus. In a transverse section, a particle (or cell) experiences simultaneously gravitational, Archimedes, centrifugal, Coriolis, and drag forces. In a frame of reference rotating with angular velocity ω, the particle follows a periodic nearly circular path in the clockwise direction, associated with a very slow centrifugal drift towards the esophagus wall. It appears that moderate perfusion rate and rotation speed (ω < 20 rpm and Q < 30 ml/min) are appropriate experimental conditions for esophagus tissue engineering using the RCCS Synthecon bioreactor.Read less <
English Keywords
Esophageal substitute
Rotating bioreactor
Spiral Poiseuille flow
Tissue engineering
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