Fluid dynamics characterisation of a rotating bioreactor for tissue engineering
| dc.rights.license | open | en_US |
| hal.structure.identifier | Université de Technologie de Compiègne [UTC] | |
| hal.structure.identifier | Centre National de la Recherche Scientifique [CNRS] | |
| hal.structure.identifier | Biomécanique et Bioingénierie [BMBI] | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | DROCHON, Agnes | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | LESIEUR, Romane | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | DURAND, Marlène | |
| dc.date.accessioned | 2023-04-04T09:39:54Z | |
| dc.date.available | 2023-04-04T09:39:54Z | |
| dc.date.issued | 2022-07-01 | |
| dc.identifier.issn | 1350-4533 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172717 | |
| dc.description.abstractEn | Biological scaffolds composed of extracellular matrix (ECM) derived from decellularised tissue are increasingly used in regenerative medicine. In this project, a flow perfusion bioreactor (the rotary cell culture system (RCCS), commercially available from Synthecon (Houston, TX)) is used in order to obtain some esophageal extracellular matrix. A theoretical mechanical characterisation of this experimental set-up is provided. Due to the combination of rotation and perfusion, some spiral Poiseuille flow is created inside the tubular esophagus. In a transverse section, a particle (or cell) experiences simultaneously gravitational, Archimedes, centrifugal, Coriolis, and drag forces. In a frame of reference rotating with angular velocity ω, the particle follows a periodic nearly circular path in the clockwise direction, associated with a very slow centrifugal drift towards the esophagus wall. It appears that moderate perfusion rate and rotation speed (ω < 20 rpm and Q < 30 ml/min) are appropriate experimental conditions for esophagus tissue engineering using the RCCS Synthecon bioreactor. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Esophageal substitute | |
| dc.subject.en | Rotating bioreactor | |
| dc.subject.en | Spiral Poiseuille flow | |
| dc.subject.en | Tissue engineering | |
| dc.title.en | Fluid dynamics characterisation of a rotating bioreactor for tissue engineering | |
| dc.title.alternative | Med Eng Phys | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.medengphy.2022.103831 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| bordeaux.journal | Medical Engineering & Physics | en_US |
| bordeaux.volume | 105 | en_US |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.institution | Institut Bergonié | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Medical%20Engineering%20&%20Physics&rft.date=2022-07-01&rft.volume=105&rft.eissn=1350-4533&rft.issn=1350-4533&rft.au=DROCHON,%20Agnes&LESIEUR,%20Romane&DURAND,%20Marl%C3%A8ne&rft.genre=article |
