DROCHON, Agnes; LESIEUR, Romane; DURAND, Marlène

doi:10.1016/j.medengphy.2022.103831

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DROCHON, Agnes
Université de Technologie de Compiègne [UTC]
Centre National de la Recherche Scientifique [CNRS]
Biomécanique et Bioingénierie [BMBI]
Institut de Mécanique et d'Ingénierie [I2M]

LESIEUR, Romane
Bioingénierie tissulaire [BIOTIS]

DURAND, Marlène
Bioingénierie tissulaire [BIOTIS]

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Medical Engineering & Physics. 2022-07-01, vol. 105

Resumen en inglés

Biological scaffolds composed of extracellular matrix (ECM) derived from decellularised tissue are increasingly used in regenerative medicine. In this project, a flow perfusion bioreactor (the rotary cell culture system (RCCS), commercially available from Synthecon (Houston, TX)) is used in order to obtain some esophageal extracellular matrix. A theoretical mechanical characterisation of this experimental set-up is provided. Due to the combination of rotation and perfusion, some spiral Poiseuille flow is created inside the tubular esophagus. In a transverse section, a particle (or cell) experiences simultaneously gravitational, Archimedes, centrifugal, Coriolis, and drag forces. In a frame of reference rotating with angular velocity ω, the particle follows a periodic nearly circular path in the clockwise direction, associated with a very slow centrifugal drift towards the esophagus wall. It appears that moderate perfusion rate and rotation speed (ω < 20 rpm and Q < 30 ml/min) are appropriate experimental conditions for esophagus tissue engineering using the RCCS Synthecon bioreactor.< Leer menos

Palabras clave en inglés

Esophageal substitute

Rotating bioreactor

Spiral Poiseuille flow

Tissue engineering