ZENG, Liming; PONS-MERCADE, Pere; RICHARD, Tristan; KRISA, Stephanie; TEISSEDRE, Pierre Louis; JOURDES, Michael

doi:10.3390/molecules24101915

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

ZENG, Liming
Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

PONS-MERCADE, Pere
Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

RICHARD, Tristan

Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

Langue

Article de revue

Ce document a été publié dans

Molecules. 2019, vol. 24, n° 10, p. 1-10

Résumé en anglais

The structure of a new procyanidin tetramer, which we call a crown procyanidin tetramer, with an unprecedented macrocyclic structure has been characterized for the first time. Its comprehensive spectroscopic analysis revealed that it is a symmetric procyanidin tetramer composed of four (-)-epicatechin sub-units linked alternatively via 4β→8 or 4β→6 B-type interflavanyl linkages to form the macrocyclic structure. This NMR-characterized carbon skeleton has never been reported before for procyanidins in grape or in wine, neither in the plant kingdom. Surprisingly, the crown procyanidin tetramer appeared to be specifically localized in grape skin, contrasting with the oligomeric and polymeric procyanidins present in seed, skin, and bunch stem. Moreover, this crown procyanidin tetramer showed promising protective effects against amyloid-β induced toxicity.< Réduire

Mots clés en anglais

Condensed Tannin

Crown Procyanidin

Grape

Procyanidin

Red Wine

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Crown procyanidin tetramer: a procyanidin with an unusual cyclic skeleton with a potent protective effect against amyloid-β-induced toxicity

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche