Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
Language
EN
Article de revue
This item was published in
Antimicrobial Agents and Chemotherapy. 2008-10-01, vol. 52, n° 10, p. 3792-4
English Abstract
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution ...Read more >
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.Read less <
English Keywords
Aged
Amino Acid Substitution
Base Sequence
DNA Primers
DNA
Bacterial
Female
Genes
Bacterial
Humans
Isoelectric Point
Kinetics
Klebsiella Infections
Klebsiella pneumoniae
Molecular Sequence Data
Mutagenesis
Insertional
Recombinant Proteins
beta-Lactam Resistance
beta-Lactamases