Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
Langue
EN
Article de revue
Ce document a été publié dans
Antimicrobial Agents and Chemotherapy. 2008-10-01, vol. 52, n° 10, p. 3792-4
Résumé en anglais
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution ...Lire la suite >
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.< Réduire
Mots clés en anglais
Aged
Amino Acid Substitution
Base Sequence
DNA Primers
DNA
Bacterial
Female
Genes
Bacterial
Humans
Isoelectric Point
Kinetics
Klebsiella Infections
Klebsiella pneumoniae
Molecular Sequence Data
Mutagenesis
Insertional
Recombinant Proteins
beta-Lactam Resistance
beta-Lactamases
Unités de recherche