Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
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EN
Article de revue
Este ítem está publicado en
Antimicrobial Agents and Chemotherapy. 2008-10-01, vol. 52, n° 10, p. 3792-4
Resumen en inglés
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution ...Leer más >
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.< Leer menos
Palabras clave en inglés
Aged
Amino Acid Substitution
Base Sequence
DNA Primers
DNA
Bacterial
Female
Genes
Bacterial
Humans
Isoelectric Point
Kinetics
Klebsiella Infections
Klebsiella pneumoniae
Molecular Sequence Data
Mutagenesis
Insertional
Recombinant Proteins
beta-Lactam Resistance
beta-Lactamases
Centros de investigación