SARRAZY, Vincent; VEDRENNE, Nicolas; BILLET, Fabrice; BORDEAU, Nelly; LEPREUX, Sébastien; VITAL, Anne; JAUBERTEAU-MARCHAN, Marie-Odile; DESMOULIÈRE, Alexis

doi:10.1016/j.canlet.2011.07.018

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SARRAZY, Vincent
Maintenance Myélinique et Neuropathies Périphériques [MMNP]

VEDRENNE, Nicolas
Maintenance Myélinique et Neuropathies Périphériques [MMNP]

BILLET, Fabrice
Maintenance Myélinique et Neuropathies Périphériques [MMNP]

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Cancer Letters. 2011-12-08, vol. 311, n° 2, p. 195-202

Elsevier

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The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment. Activation of the Fas pathway or of the TLR4 pathway induced cell proliferation. However, simultaneous treatment with agonist antibody and LPS decreased proliferation. This anti-proliferative effect was caspase dependent, and a decreased cell migration and matrix metalloproteinase (MMP)-9 expression were also observed. Both TLR4 and MMP-9 were highly expressed in human glioblastoma tissues. These data suggest that TLR4 signal transduction pathways neutralize proliferation and migration induced by Fas pathway activation in glioblastoma cell lines.< Réduire

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TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.

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