TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.
JAUBERTEAU-MARCHAN, Marie-Odile
Homéostasie Cellulaire et Pathologies [HCP]
Service d'Immunologie et immunogénétique [CHU Limoges]
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Homéostasie Cellulaire et Pathologies [HCP]
Service d'Immunologie et immunogénétique [CHU Limoges]
Language
en
Article de revue
This item was published in
Cancer Letters. 2011-12-08, vol. 311, n° 2, p. 195-202
Elsevier
English Abstract
The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the ...Read more >
The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment. Activation of the Fas pathway or of the TLR4 pathway induced cell proliferation. However, simultaneous treatment with agonist antibody and LPS decreased proliferation. This anti-proliferative effect was caspase dependent, and a decreased cell migration and matrix metalloproteinase (MMP)-9 expression were also observed. Both TLR4 and MMP-9 were highly expressed in human glioblastoma tissues. These data suggest that TLR4 signal transduction pathways neutralize proliferation and migration induced by Fas pathway activation in glioblastoma cell lines.Read less <
Origin
Hal importedCollections