TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.
hal.structure.identifier | Maintenance Myélinique et Neuropathies Périphériques [MMNP] | |
dc.contributor.author | SARRAZY, Vincent | |
hal.structure.identifier | Maintenance Myélinique et Neuropathies Périphériques [MMNP] | |
dc.contributor.author | VEDRENNE, Nicolas | |
hal.structure.identifier | Maintenance Myélinique et Neuropathies Périphériques [MMNP] | |
dc.contributor.author | BILLET, Fabrice | |
dc.contributor.author | BORDEAU, Nelly | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | LEPREUX, Sébastien | |
hal.structure.identifier | Service de pathologie [Bordeaux] | |
dc.contributor.author | VITAL, Anne | |
hal.structure.identifier | Homéostasie Cellulaire et Pathologies [HCP] | |
hal.structure.identifier | Service d'Immunologie et immunogénétique [CHU Limoges] | |
dc.contributor.author | JAUBERTEAU-MARCHAN, Marie-Odile | |
hal.structure.identifier | Maintenance Myélinique et Neuropathies Périphériques [MMNP] | |
dc.contributor.author | DESMOULIÈRE, Alexis | |
dc.date.accessioned | 2021-06-10T07:05:58Z | |
dc.date.available | 2021-06-10T07:05:58Z | |
dc.date.issued | 2011-12-08 | |
dc.identifier.issn | 0304-3835 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/79055 | |
dc.description.abstractEn | The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment. Activation of the Fas pathway or of the TLR4 pathway induced cell proliferation. However, simultaneous treatment with agonist antibody and LPS decreased proliferation. This anti-proliferative effect was caspase dependent, and a decreased cell migration and matrix metalloproteinase (MMP)-9 expression were also observed. Both TLR4 and MMP-9 were highly expressed in human glioblastoma tissues. These data suggest that TLR4 signal transduction pathways neutralize proliferation and migration induced by Fas pathway activation in glioblastoma cell lines. | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.subject.mesh | Antigens, CD95 | |
dc.subject.mesh | Cell Line, Tumor | |
dc.subject.mesh | Cell Movement | |
dc.subject.mesh | Cell Proliferation | |
dc.subject.mesh | Glioblastoma | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunohistochemistry | |
dc.subject.mesh | Matrix Metalloproteinase 9 | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Toll-Like Receptor 4 | |
dc.title.en | TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration. | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.canlet.2011.07.018 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biologie cellulaire | |
bordeaux.journal | Cancer Letters | |
bordeaux.page | 195-202 | |
bordeaux.volume | 311 | |
bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | * |
bordeaux.issue | 2 | |
bordeaux.institution | CNRS | |
bordeaux.institution | INSERM | |
bordeaux.institution | CHU de Bordeaux | |
bordeaux.institution | Institut Bergonié | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00873131 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00873131v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancer%20Letters&rft.date=2011-12-08&rft.volume=311&rft.issue=2&rft.spage=195-202&rft.epage=195-202&rft.eissn=0304-3835&rft.issn=0304-3835&rft.au=SARRAZY,%20Vincent&VEDRENNE,%20Nicolas&BILLET,%20Fabrice&BORDEAU,%20Nelly&LEPREUX,%20S%C3%A9bastien&rft.genre=article |
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