GHRIBI, Lotfi; WAFFO TEGUO, Pierre; CLUZET, Stephanie; MARCHAL, Axel; MARQUES, Jessica; MERILLON, Jean-Michel; BEN JANNET, Hichem

doi:10.1016/j.bmcl.2015.07.076

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

GHRIBI, Lotfi

WAFFO TEGUO, Pierre

Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

CLUZET, Stephanie

Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

Idioma

Article de revue

Este ítem está publicado en

Bioorganic and Medicinal Chemistry Letters. 2015-09-15, vol. 25, n° 18, p. 3825-30

Resumen en inglés

A phytochemical investigation of the roots of Ononis angustissima L. (Fabaceae) offered to the bio-guided isolation of new isoflavone 3-(4-(glucopyranosyloxy)-5-hydroxy-2-methoxyphenyl)-7-hydroxy-4H-chromen-4-one 1, together with nine known compounds, ononin 2, formononetin 3, (+)-puerol A-2'-O-β-D-glucose 4, (-)-puerol B-2'-O-β-D-glucopyranose ((-)-sophoraside A) 5, (+)-puerol A 6, (-)-trifolirhizin 7, (-)-trifolirhizin-6'-O-malonate 8, (-)-maackiain 9 and (-)-medicarpin 10. Compounds 2-10 were isolated and identified for the first time in Ononis angustissima. We investigated antioxidant capacities of isolated molecules and results showed that compound 6 exhibited the highest antioxidant activity with IC50 values of 19.53 μg/mL, 28.29 μg/mL and 38.53 μg/mL by DPPH radical, ABTS radical cation and reducing power assay, respectively, and an interesting IC50 (20.45 μg/mL) of 1 against DPPH. In addition, the neuroprotective activity of six isolated molecules (4-7, 9, 10) were evaluated. Following the exposure of PC12 cells to Aβ25-35, compounds 9 and 10 triggered a significant increase of cell viability and in a dose dependent manner.< Leer menos

Palabras clave en inglés

Animals

Antioxidants

Benzothiazoles

Biphenyl Compounds

Cell Survival

Dose-Response Relationship

Drug

Free Radicals

Molecular Structure

Ononis

PC12 Cells

Picrates

Plant Extracts

Plant Roots

Rats

Structure-Activity Relationship

Sulfonic Acids

Tunisia

Metadatos

Compartir este ítem

Licencia de uso del documento

Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L.

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación