Metadata
Show full item recordShare this item!
Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
VALLÉE, Monique
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
VALLÉE, Monique
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Language
EN
Article de revue
This item was published in
Frontiers in Neuroendocrinology. 2024-01, vol. 72
English Abstract
Advances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according ...Read more >
Advances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analysis of steroids is a key feature of their interactions with the phospholipid membrane, receptors and resulting activity. Therefore, mass spectrometry-based methods have been developed to elucidate the metabolic pathways of steroids, the ultimate approach being metabolomics, which allows the identification of a large number of metabolites in a single sample. This approach should enable us to make progress in understanding the role of neurosteroids in the functioning of physiological and pathological processes. © 2023 Elsevier Inc.Read less <
English Keywords
CB1R
Homeostasis
Mass spectrometry
Membrane receptors
Metabolomics
Neuroendocrinology
Neuromodulation
Neurosteroids
Pregnenolone
Sites of steroid production
ANR Project
Étude des mécanismes cellulaires et moléculaires qui constituent la boucle de régulation PREG-CB1R dans des conditions physiologiques et pathologiques - ANR-22-CE16-0017
Collections