Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | VALLÉE, Monique | |
| dc.date.accessioned | 2025-05-26T14:38:05Z | |
| dc.date.available | 2025-05-26T14:38:05Z | |
| dc.date.issued | 2024-01 | |
| dc.identifier.issn | 0091-3022 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206720 | |
| dc.description.abstractEn | Advances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analysis of steroids is a key feature of their interactions with the phospholipid membrane, receptors and resulting activity. Therefore, mass spectrometry-based methods have been developed to elucidate the metabolic pathways of steroids, the ultimate approach being metabolomics, which allows the identification of a large number of metabolites in a single sample. This approach should enable us to make progress in understanding the role of neurosteroids in the functioning of physiological and pathological processes. © 2023 Elsevier Inc. | |
| dc.description.sponsorship | Étude des mécanismes cellulaires et moléculaires qui constituent la boucle de régulation PREG-CB1R dans des conditions physiologiques et pathologiques - ANR-22-CE16-0017 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | CB1R | |
| dc.subject.en | Homeostasis | |
| dc.subject.en | Mass spectrometry | |
| dc.subject.en | Membrane receptors | |
| dc.subject.en | Metabolomics | |
| dc.subject.en | Neuroendocrinology | |
| dc.subject.en | Neuromodulation | |
| dc.subject.en | Neurosteroids | |
| dc.subject.en | Pregnenolone | |
| dc.subject.en | Sites of steroid production | |
| dc.title.en | Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function | |
| dc.title.alternative | Front Neuroendocrinol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.yfrne.2023.101113 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 37993022 | en_US |
| bordeaux.journal | Frontiers in Neuroendocrinology | en_US |
| bordeaux.volume | 72 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie et approches thérapeutiques des maladies liées au stress | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05085472 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-05-26T14:38:07Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Neuroendocrinology&rft.date=2024-01&rft.volume=72&rft.eissn=0091-3022&rft.issn=0091-3022&rft.au=VALL%C3%89E,%20Monique&rft.genre=article |