VALLÉE, Monique

doi:10.1016/j.yfrne.2023.101113

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VALLÉE, Monique
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Frontiers in Neuroendocrinology. 2024-01, vol. 72

Résumé en anglais

Advances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analysis of steroids is a key feature of their interactions with the phospholipid membrane, receptors and resulting activity. Therefore, mass spectrometry-based methods have been developed to elucidate the metabolic pathways of steroids, the ultimate approach being metabolomics, which allows the identification of a large number of metabolites in a single sample. This approach should enable us to make progress in understanding the role of neurosteroids in the functioning of physiological and pathological processes. © 2023 Elsevier Inc.< Réduire

Mots clés en anglais

CB1R

Homeostasis

Mass spectrometry

Membrane receptors

Metabolomics

Neuroendocrinology

Neuromodulation

Neurosteroids

Pregnenolone

Sites of steroid production

URI

https://oskar-bordeaux.fr/handle/20.500.12278/206720

DOI

http://dx.doi.org/10.1016/j.yfrne.2023.101113

Project ANR

Étude des mécanismes cellulaires et moléculaires qui constituent la boucle de régulation PREG-CB1R dans des conditions physiologiques et pathologiques - ANR-22-CE16-0017

Unités de recherche

Neurocentre Magendie - U1215