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Novel insights into D-Pinitol based therapies: A link between tau hyperphosphorylation and insulin resistance
LÓPEZ-GAMBERO, Antonio Jesús
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
LÓPEZ-GAMBERO, Antonio Jesús
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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EN
Article de revue
This item was published in
Neural Regeneration Research. 2024-02, vol. 19, n° 2, p. 289 – 295
English Abstract
Alzheimer's disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer's disease. The pathogenesis of Alzheimer's disease is mainly mediated by the phosphorylation ...Read more >
Alzheimer's disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer's disease. The pathogenesis of Alzheimer's disease is mainly mediated by the phosphorylation and aggregation of tau protein. Among the multiple causes of tau hyperphosphorylation, brain insulin resistance has generated much attention, and inositols as insulin sensitizers, are currently considered candidates for drug development. The present narrative review revises the interactions between these three elements: Alzheimer's disease-tau-inositols, which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease. © 2024 Wolters Kluwer Medknow Publications. All rights reserved.Read less <
English Keywords
Alzheimer’s disease
D-Pinitol
PI3K/Akt
Cyclin-dependent kinase 5
Diabetes
Inositols
Insulin resistance
Kinases
Phosphorylation
Tau
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