MEDINA-VERA, Dina; LÓPEZ-GAMBERO, Antonio Jesús; NAVARRO, Juan Antonio; SANJUAN, Carlos; BAIXERAS, Elena; DECARA, Juan; DE FONSECA, Fernando Rodríguez

doi:10.4103/1673-5374.379015

LÓPEZ-GAMBERO, Antonio Jesús
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

NAVARRO, Juan Antonio

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Article de revue

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Neural Regeneration Research. 2024-02, vol. 19, n° 2, p. 289 – 295

Resumen en inglés

Alzheimer's disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer's disease. The pathogenesis of Alzheimer's disease is mainly mediated by the phosphorylation and aggregation of tau protein. Among the multiple causes of tau hyperphosphorylation, brain insulin resistance has generated much attention, and inositols as insulin sensitizers, are currently considered candidates for drug development. The present narrative review revises the interactions between these three elements: Alzheimer's disease-tau-inositols, which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease. © 2024 Wolters Kluwer Medknow Publications. All rights reserved.< Leer menos

Palabras clave en inglés

Alzheimer’s disease

D-Pinitol

PI3K/Akt

Cyclin-dependent kinase 5

Diabetes

Inositols

Insulin resistance

Kinases

Phosphorylation

Tau

URI

https://oskar-bordeaux.fr/handle/20.500.12278/206654

DOI

http://dx.doi.org/10.4103/1673-5374.379015

Centros de investigación

Neurocentre Magendie - U1215

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Novel insights into D-Pinitol based therapies: A link between tau hyperphosphorylation and insulin resistance

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Palabras clave en inglés

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Centros de investigación