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Novel insights into D-Pinitol based therapies: A link between tau hyperphosphorylation and insulin resistance
LÓPEZ-GAMBERO, Antonio Jesús
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
LÓPEZ-GAMBERO, Antonio Jesús
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Réduire
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Langue
EN
Article de revue
Ce document a été publié dans
Neural Regeneration Research. 2024-02, vol. 19, n° 2, p. 289 – 295
Résumé en anglais
Alzheimer's disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer's disease. The pathogenesis of Alzheimer's disease is mainly mediated by the phosphorylation ...Lire la suite >
Alzheimer's disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer's disease. The pathogenesis of Alzheimer's disease is mainly mediated by the phosphorylation and aggregation of tau protein. Among the multiple causes of tau hyperphosphorylation, brain insulin resistance has generated much attention, and inositols as insulin sensitizers, are currently considered candidates for drug development. The present narrative review revises the interactions between these three elements: Alzheimer's disease-tau-inositols, which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease. © 2024 Wolters Kluwer Medknow Publications. All rights reserved.< Réduire
Mots clés en anglais
Alzheimer’s disease
D-Pinitol
PI3K/Akt
Cyclin-dependent kinase 5
Diabetes
Inositols
Insulin resistance
Kinases
Phosphorylation
Tau
Unités de recherche