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The effect of unloading and ejection conditions on the properties of pharmaceutical tablets
MAZEL, Vincent
Université de Bordeaux [UB]
Centre National de la Recherche Scientifique [CNRS]
Institut de Mécanique et d'Ingénierie de Bordeaux [I2M-BX]
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Université de Bordeaux [UB]
Centre National de la Recherche Scientifique [CNRS]
Institut de Mécanique et d'Ingénierie de Bordeaux [I2M-BX]
MAZEL, Vincent
Université de Bordeaux [UB]
Centre National de la Recherche Scientifique [CNRS]
Institut de Mécanique et d'Ingénierie de Bordeaux [I2M-BX]
< Reduce
Université de Bordeaux [UB]
Centre National de la Recherche Scientifique [CNRS]
Institut de Mécanique et d'Ingénierie de Bordeaux [I2M-BX]
Language
EN
Article de revue
This item was published in
International Journal of Pharmaceutics. 2024-06-10, vol. 658, p. 124150
English Abstract
This study investigates decompression and ejection conditions on tablet characteristics by comparing compact densities and tensile strengths made using regular rigid dies and custom-built die systems that enable triaxial ...Read more >
This study investigates decompression and ejection conditions on tablet characteristics by comparing compact densities and tensile strengths made using regular rigid dies and custom-built die systems that enable triaxial decompression. Die-wall pressure evolution during decompression and ejection stresses did not meaningfully impact the density and tensile strength of the materials tested: microcrystalline cellulose, crystalline lactose monohydrate, and mannitol. Furthermore, the apparent differences in tensile strength between rectangular cuboids and cylindrical compacts are unrelated to decompression and ejection conditions, but rather a consequence of their shapes and of the test configurations. This suggests that elastic and plastic deformations that may occur during decompression and ejection are not significantly influenced by die-wall pressure evolution. We thus conclude that while triaxial decompression and constraint-free ejection may allow the production of defect-free compacts for materials that otherwise are defect prone using a rigid die, they seem to pose no benefits when the materials already produce defect-free compacts using a rigid die.Read less <
English Keywords
Mechanical properties
Pharmaceutical powder
Powder compaction
Tableting
Tensile strength
Triaxial decompression