The effect of unloading and ejection conditions on the properties of pharmaceutical tablets
| dc.rights.license | open | en_US |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| hal.structure.identifier | Centre National de la Recherche Scientifique [CNRS] | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | MAZEL, Vincent
IDREF: 113057954 | |
| dc.contributor.author | YOST, Edward | |
| dc.contributor.author | SLUGA, Kellie | |
| dc.contributor.author | NAGAPUDI, Karthik | |
| dc.contributor.author | MULIADI, Ariel R | |
| dc.date.accessioned | 2024-07-12T08:23:41Z | |
| dc.date.available | 2024-07-12T08:23:41Z | |
| dc.date.issued | 2024-06-10 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200886 | |
| dc.description.abstractEn | This study investigates decompression and ejection conditions on tablet characteristics by comparing compact densities and tensile strengths made using regular rigid dies and custom-built die systems that enable triaxial decompression. Die-wall pressure evolution during decompression and ejection stresses did not meaningfully impact the density and tensile strength of the materials tested: microcrystalline cellulose, crystalline lactose monohydrate, and mannitol. Furthermore, the apparent differences in tensile strength between rectangular cuboids and cylindrical compacts are unrelated to decompression and ejection conditions, but rather a consequence of their shapes and of the test configurations. This suggests that elastic and plastic deformations that may occur during decompression and ejection are not significantly influenced by die-wall pressure evolution. We thus conclude that while triaxial decompression and constraint-free ejection may allow the production of defect-free compacts for materials that otherwise are defect prone using a rigid die, they seem to pose no benefits when the materials already produce defect-free compacts using a rigid die. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Mechanical properties | |
| dc.subject.en | Pharmaceutical powder | |
| dc.subject.en | Powder compaction | |
| dc.subject.en | Tableting | |
| dc.subject.en | Tensile strength | |
| dc.subject.en | Triaxial decompression | |
| dc.title.en | The effect of unloading and ejection conditions on the properties of pharmaceutical tablets | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.ijpharm.2024.124150 | en_US |
| dc.subject.hal | Sciences de l'ingénieur [physics]/Matériaux | en_US |
| dc.identifier.pubmed | 38663645 | en_US |
| bordeaux.journal | International Journal of Pharmaceutics | en_US |
| bordeaux.page | 124150 | en_US |
| bordeaux.volume | 658 | en_US |
| bordeaux.hal.laboratories | Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | Arts et Métiers | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04645963 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-07-12T08:23:43Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Pharmaceutics&rft.date=2024-06-10&rft.volume=658&rft.spage=124150&rft.epage=124150&rft.au=MAZEL,%20Vincent&YOST,%20Edward&SLUGA,%20Kellie&NAGAPUDI,%20Karthik&MULIADI,%20Ariel%20R&rft.genre=article |
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