GOMEZ-ZORITA, Saioa; MILTON-LASKIBAR, Iñaki; ESEBERRI, Itziar; BEAUMONT, Pauline; COURTOIS, Arnaud; KRISA, Stéphanie; PORTILLO, María P

doi:10.3390/nu15040928

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Nutrients. 2023-02-12, vol. 15, n° 4, p. 928

Résumé en anglais

Viniferin is a phenolic compound belonging to the group of stilbenoids. In particular, ε-viniferin is a dimer of resveratrol, found in many plant genders, among which grapes (Vitis vinifera) are a primary source. Due to the fact that ε-viniferin is mainly present in the woody parts of plants, their use as a source of this bioactive compound is a very interesting issue in a circular economy. Both, in vitro studies carried out in pre-adipocytes and mature adipocytes and in vivo studies addressed in mice show that ε-viniferin is able to reduce fat accumulation. Moreover, it prevents the development of some obesity co-morbidities, such as type 2 diabetes, dyslipidemias, hypertension and fatty liver. ε-viniferin can be absorbed orally, but it shows a very low bioavailability. In this scenario, further research on animal models is needed to confirm the effects reported in a great number of studies; to determine which metabolites are involved, including the main one responsible for the biological effects observed and the mechanisms that justify these effects. In a further phase, human studies should be addressed in order to use ε-viniferin as a new tool for obesity management, as a nutraceutical or to be included in functional foods. © 2023 by the authors.< Réduire

Mots clés en anglais

viniferin

obesity

glucose homeostasis

dyslipidemia

fatty liver

hypertension

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https://oskar-bordeaux.fr/handle/20.500.12278/197568

DOI

http://dx.doi.org/10.3390/nu15040928

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Oenologie - UMR 1366

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Beneficial Effects of ϵ-Viniferin on Obesity and Related Health Alterations

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