GINIP, a Gαi-Interacting Protein, Functions as a Key Modulator of Peripheral GABAB Receptor-Mediated Analgesia
GAILLARD, Stéphane
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
LO RE, Laure
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
See more >
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
GAILLARD, Stéphane
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
LO RE, Laure
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
ALONSO, Serge
Institut de Mathématiques de Bordeaux [IMB]
Développement et pathologies du système nerveux : croissance, signalisation et innovation moléculaire
Institut de Mathématiques de Bordeaux [IMB]
Développement et pathologies du système nerveux : croissance, signalisation et innovation moléculaire
SCHERRER, Grégory
Departments of Anatomy and Physiology and W. M. Keck Center for Integrative Neuroscience
Departments of Anatomy and Physiology and W. M. Keck Center for Integrative Neuroscience
MOQRICH, Aziz
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
< Reduce
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]
Language
en
Article de revue
This item was published in
Neuron. 2014-09-17, vol. 84, n° 1, p. 123–136
Elsevier
English Abstract
One feature of neuropathic pain is a reduced GABAergic inhibitory function. Nociceptors have been suggested to play a key role in this process. However, the mechanisms behind nociceptor-mediated modulation of GABA signaling ...Read more >
One feature of neuropathic pain is a reduced GABAergic inhibitory function. Nociceptors have been suggested to play a key role in this process. However, the mechanisms behind nociceptor-mediated modulation of GABA signaling remain to be elucidated. Here we describe the identification of GINIP, a Gαi-interacting protein expressed in two distinct subsets of nonpeptidergic nociceptors. GINIP null mice develop a selective and prolonged mechanical hypersensitivity in models of inflammation and neuropathy. GINIP null mice show impaired responsiveness to GABAB, but not to delta or mu opioid receptor agonist-mediated analgesia specifically in the spared nerve injury (SNI) model. Consistently, GINIP-deficient dorsal root ganglia neurons had lower baclofen-evoked inhibition of high-voltage-activated calcium channels and a defective presynaptic inhibition of lamina IIi interneurons. These results further support the role of unmyelinated C fibers in injury-induced modulation of spinal GABAergic inhibition and identify GINIP as a key modulator of peripherally evoked GABAB-receptors signaling.Read less <
English Keywords
Nonpeptidergic nociceptors
GINIP
Mice
Injury
Analgesia
European Project
Functional significance of nociceptive primary sensory neurons diversity
Origin
Hal imported