GAILLARD, Stéphane; LO RE, Laure; MANTILLERI, Annabelle; HEPP, Régine; URIEN, Louise; MALAPERT, Pascale; ALONSO, Serge; DEAGE, Michael; KAMBRUN, Charline; LANDRY, Marc; LOW, Sarah A; ALLOUI, Abdelkrim; LAMBOLEZ, Bertrand; SCHERRER, Grégory; LE FEUVRE, Yves; BOURINET, Emmanuel; MOQRICH, Aziz

doi:10.1016/j.neuron.2014.08.056

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Licence d’utilisation du document

GAILLARD, Stéphane
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]

LO RE, Laure
Institut de Mathématiques de Bordeaux [IMB]
Institut de Biologie du Développement de Marseille [IBDM]

MANTILLERI, Annabelle
Institut de Mathématiques de Bordeaux [IMB]

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Article de revue

Ce document a été publié dans

Neuron. 2014-09-17, vol. 84, n° 1, p. 123–136

Elsevier

Résumé en anglais

One feature of neuropathic pain is a reduced GABAergic inhibitory function. Nociceptors have been suggested to play a key role in this process. However, the mechanisms behind nociceptor-mediated modulation of GABA signaling remain to be elucidated. Here we describe the identification of GINIP, a Gαi-interacting protein expressed in two distinct subsets of nonpeptidergic nociceptors. GINIP null mice develop a selective and prolonged mechanical hypersensitivity in models of inflammation and neuropathy. GINIP null mice show impaired responsiveness to GABAB, but not to delta or mu opioid receptor agonist-mediated analgesia specifically in the spared nerve injury (SNI) model. Consistently, GINIP-deficient dorsal root ganglia neurons had lower baclofen-evoked inhibition of high-voltage-activated calcium channels and a defective presynaptic inhibition of lamina IIi interneurons. These results further support the role of unmyelinated C fibers in injury-induced modulation of spinal GABAergic inhibition and identify GINIP as a key modulator of peripherally evoked GABAB-receptors signaling.< Réduire

Mots clés en anglais

Nonpeptidergic nociceptors

GINIP

Mice

Injury

Analgesia

URI

https://oskar-bordeaux.fr/handle/20.500.12278/193116

DOI

http://dx.doi.org/10.1016/j.neuron.2014.08.056

Projet Européen

Functional significance of nociceptive primary sensory neurons diversity

Origine

Importé de hal

Unités de recherche

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251