Afficher la notice abrégée

GINIP, a Gαi-Interacting Protein, Functions as a Key Modulator of Peripheral GABAB Receptor-Mediated Analgesia

hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierInstitut de Biologie du Développement de Marseille [IBDM]
dc.contributor.authorGAILLARD, Stéphane
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierInstitut de Biologie du Développement de Marseille [IBDM]
dc.contributor.authorLO RE, Laure
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorMANTILLERI, Annabelle
hal.structure.identifierNeurobiologie des processus adaptatifs [NPA]
dc.contributor.authorHEPP, Régine
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorURIEN, Louise
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorMALAPERT, Pascale
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierDéveloppement et pathologies du système nerveux : croissance, signalisation et innovation moléculaire
dc.contributor.authorALONSO, Serge
dc.contributor.authorDEAGE, Michael
dc.contributor.authorKAMBRUN, Charline
hal.structure.identifierPhysiopathologie des Reseaux Neuronaux Medullaires
dc.contributor.authorLANDRY, Marc
dc.contributor.authorLOW, Sarah A
hal.structure.identifierPharmacologie fondamentale et clinique de la douleur
dc.contributor.authorALLOUI, Abdelkrim
hal.structure.identifierNeurobiologie des processus adaptatifs [NPA]
dc.contributor.authorLAMBOLEZ, Bertrand
hal.structure.identifierDepartments of Anatomy and Physiology and W. M. Keck Center for Integrative Neuroscience
dc.contributor.authorSCHERRER, Grégory
dc.contributor.authorLE FEUVRE, Yves
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorBOURINET, Emmanuel
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierInstitut de Biologie du Développement de Marseille [IBDM]
dc.contributor.authorMOQRICH, Aziz
dc.date.accessioned2024-04-04T03:04:03Z
dc.date.available2024-04-04T03:04:03Z
dc.date.issued2014-09-17
dc.identifier.issn0896-6273
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193116
dc.description.abstractEnOne feature of neuropathic pain is a reduced GABAergic inhibitory function. Nociceptors have been suggested to play a key role in this process. However, the mechanisms behind nociceptor-mediated modulation of GABA signaling remain to be elucidated. Here we describe the identification of GINIP, a Gαi-interacting protein expressed in two distinct subsets of nonpeptidergic nociceptors. GINIP null mice develop a selective and prolonged mechanical hypersensitivity in models of inflammation and neuropathy. GINIP null mice show impaired responsiveness to GABAB, but not to delta or mu opioid receptor agonist-mediated analgesia specifically in the spared nerve injury (SNI) model. Consistently, GINIP-deficient dorsal root ganglia neurons had lower baclofen-evoked inhibition of high-voltage-activated calcium channels and a defective presynaptic inhibition of lamina IIi interneurons. These results further support the role of unmyelinated C fibers in injury-induced modulation of spinal GABAergic inhibition and identify GINIP as a key modulator of peripherally evoked GABAB-receptors signaling.
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enNonpeptidergic nociceptors
dc.subject.enGINIP
dc.subject.enMice
dc.subject.enInjury
dc.subject.enAnalgesia
dc.title.enGINIP, a Gαi-Interacting Protein, Functions as a Key Modulator of Peripheral GABAB Receptor-Mediated Analgesia
dc.typeArticle de revue
dc.identifier.doi10.1016/j.neuron.2014.08.056
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
dc.description.sponsorshipEuropeFunctional significance of nociceptive primary sensory neurons diversity
bordeaux.journalNeuron
bordeaux.page123–136
bordeaux.volume84
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01071132
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01071132v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuron&rft.date=2014-09-17&rft.volume=84&rft.issue=1&rft.spage=123%E2%80%93136&rft.epage=123%E2%80%93136&rft.eissn=0896-6273&rft.issn=0896-6273&rft.au=GAILLARD,%20St%C3%A9phane&LO%20RE,%20Laure&MANTILLERI,%20Annabelle&HEPP,%20R%C3%A9gine&URIEN,%20Louise&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée