Efficient estimation of cardiac conductivities: A proper generalized decomposition approach
BARONE, Alessandro
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
CARLINO, Michele Giuliano
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
See more >
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
BARONE, Alessandro
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
CARLINO, Michele Giuliano
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
< Reduce
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
Language
en
Article de revue
This item was published in
Journal of Computational Physics. 2020-09p. 109810
Elsevier
English Abstract
While the potential groundbreaking role of mathematical modeling in electrophysiology has been demon-strated for therapies like cardiac resynchronization or catheter ablation, its extensive use in clinics is pre-vented by ...Read more >
While the potential groundbreaking role of mathematical modeling in electrophysiology has been demon-strated for therapies like cardiac resynchronization or catheter ablation, its extensive use in clinics is pre-vented by the need of an accurate customized conductivity identification. Data assimilation techniques are,in general, used to identify parameters that cannot be measured directly, especially in patient-specific set-tings. Yet, they may be computationally demanding. This conflicts with the clinical timelines and volumesof patients to analyze. In this paper, we adopt a model reduction technique, developed by F. Chinesta andhis collaborators in the last 15 years, called Proper Generalized Decomposition (PGD), to accelerate the esti-mation of the cardiac conductivities required in the modeling of the cardiac electrical dynamics. Specifically,we resort to the Monodomain Inverse Conductivity Problem (MICP) deeply investigated in the literaturein the last five years. We provide a significant proof of concept that PGD is a breakthrough in solvingthe MICP within reasonable timelines. As PGD relies on the offline/online paradigm and does not needany preliminary knowledge of the high-fidelity solution, we show that the PGD online phase estimates theconductivities in real-time for both two-dimensional and three-dimensional cases, including a patient-specificventricle.Read less <
English Keywords
Computational Electrophysiology
Model Order Reduction
Data Assimilation
Proper Generalized Decomposition
Parameter Identification
European Project
Accurate Roms for Industrial Applications
Origin
Hal imported