Efficient estimation of cardiac conductivities: A proper generalized decomposition approach
BARONE, Alessandro
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
CARLINO, Michele Giuliano
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
Leer más >
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
BARONE, Alessandro
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
Department of Mathematics and Computer Science [Emory University]
Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM]
CARLINO, Michele Giuliano
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
< Leer menos
Modeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
Institut de Mathématiques de Bordeaux [IMB]
Idioma
en
Article de revue
Este ítem está publicado en
Journal of Computational Physics. 2020-09p. 109810
Elsevier
Resumen en inglés
While the potential groundbreaking role of mathematical modeling in electrophysiology has been demon-strated for therapies like cardiac resynchronization or catheter ablation, its extensive use in clinics is pre-vented by ...Leer más >
While the potential groundbreaking role of mathematical modeling in electrophysiology has been demon-strated for therapies like cardiac resynchronization or catheter ablation, its extensive use in clinics is pre-vented by the need of an accurate customized conductivity identification. Data assimilation techniques are,in general, used to identify parameters that cannot be measured directly, especially in patient-specific set-tings. Yet, they may be computationally demanding. This conflicts with the clinical timelines and volumesof patients to analyze. In this paper, we adopt a model reduction technique, developed by F. Chinesta andhis collaborators in the last 15 years, called Proper Generalized Decomposition (PGD), to accelerate the esti-mation of the cardiac conductivities required in the modeling of the cardiac electrical dynamics. Specifically,we resort to the Monodomain Inverse Conductivity Problem (MICP) deeply investigated in the literaturein the last five years. We provide a significant proof of concept that PGD is a breakthrough in solvingthe MICP within reasonable timelines. As PGD relies on the offline/online paradigm and does not needany preliminary knowledge of the high-fidelity solution, we show that the PGD online phase estimates theconductivities in real-time for both two-dimensional and three-dimensional cases, including a patient-specificventricle.< Leer menos
Palabras clave en inglés
Computational Electrophysiology
Model Order Reduction
Data Assimilation
Proper Generalized Decomposition
Parameter Identification
Proyecto europeo
Accurate Roms for Industrial Applications
Orígen
Importado de HalCentros de investigación