Synthesis and Crystallographic Characterization of Helical Hairpin Oligourea Foldamers
Language
EN
Article de revue
This item was published in
Chemistry - A European Journal. 2023-05-02, vol. 29, n° 39
English Abstract
AbstractOligomers designed to form a helix‐turn‐helix super‐secondary structure have been prepared by covalently bridging aliphatic oligourea foldamer helices with either rigid aromatic or more flexible aliphatic spacers. ...Read more >
AbstractOligomers designed to form a helix‐turn‐helix super‐secondary structure have been prepared by covalently bridging aliphatic oligourea foldamer helices with either rigid aromatic or more flexible aliphatic spacers. The relative helix orientation in these dimers was investigated at high resolution using X‐ray diffraction analysis. In several cases, racemic crystallography was used to facilitate crystallization and structure determination. All structures were solved by direct methods. Well‐defined parallel helical hairpin motifs were observed in all cases when 4,4′‐methylene diphenyl diisocyanate was employed as a dimerizing agent, irrespective of primary sequence and chain length.Read less <
English Keywords
Foldamers
Helices
Racemic crystallography
Tertiary structures
X-ray diffraction