PENDEM, Nagendar; NELLI, Yella‐Reddy; CUSSOL, Léonie; DIDIERJEAN, Claude; KAUFFMANN, Brice; DOLAIN, Christel; GUICHARD, Gilles

doi:10.1002/chem.202300087

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PENDEM, Nagendar
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

NELLI, Yella‐Reddy
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

CUSSOL, Léonie
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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Chemistry - A European Journal. 2023-05-02, vol. 29, n° 39

Resumen en inglés

AbstractOligomers designed to form a helix‐turn‐helix super‐secondary structure have been prepared by covalently bridging aliphatic oligourea foldamer helices with either rigid aromatic or more flexible aliphatic spacers. The relative helix orientation in these dimers was investigated at high resolution using X‐ray diffraction analysis. In several cases, racemic crystallography was used to facilitate crystallization and structure determination. All structures were solved by direct methods. Well‐defined parallel helical hairpin motifs were observed in all cases when 4,4′‐methylene diphenyl diisocyanate was employed as a dimerizing agent, irrespective of primary sequence and chain length.< Leer menos

Palabras clave en inglés

Foldamers

Helices

Racemic crystallography

Tertiary structures

X-ray diffraction