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Prevalence of faecal carriage of colistin-resistant Gram-negative rods in a university hospital in western France, 2016.
Language
EN
Article de revue
This item was published in
Journal of Medical Microbiology. 2017-06-01, vol. 66, n° 6, p. 842-843
English Abstract
Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university ...Read more >
Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university hospital in western France. From February to May 2016, rectal swabs from 653 patients hospitalized in various clinical settings were recovered and subsequently screened for colistin resistance using the SuperPolymyxin medium. Antimicrobial susceptibilities were determined according to EUCAST guidelines. Genetic detection of plasmid-mediated colistin resistance was performed by PCR. The faecal carriage with intrinsic colistin-resistant isolates was high (23 %), while the faecal carriage with Gram-negative rods showing acquired resistance was low (1.4 %). No isolate carried the plasmid-mediated mcr-1/mcr-2 genes. It was noteworthy that none of the patients carrying isolates with acquired colistin resistance had previously received a colistin-based treatment, while these isolates were not multidrug resistant.Read less <
English Keywords
Anti-Bacterial Agents
Carrier State
Colistin
Drug Resistance
Bacterial
Feces
France
Gram-Negative Bacteria
Gram-Negative Bacterial Infections
Hospitals
University
Humans
Microbial Sensitivity Tests
Polymerase Chain Reaction
Prevalence