SALY, Marion; JAYOL, Aurelie; POIREL, Laurent; MEGRAUD, Francis; NORDMANN, Patrice; DUBOIS, Veronique

doi:10.1099/jmm.0.000497

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SALY, Marion
Microbiologie Fondamentale et Pathogénicité [MFP]

JAYOL, Aurelie
Microbiologie Fondamentale et Pathogénicité [MFP]

POIREL, Laurent

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Ce document a été publié dans

Journal of Medical Microbiology. 2017-06-01, vol. 66, n° 6, p. 842-843

Résumé en anglais

Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university hospital in western France. From February to May 2016, rectal swabs from 653 patients hospitalized in various clinical settings were recovered and subsequently screened for colistin resistance using the SuperPolymyxin medium. Antimicrobial susceptibilities were determined according to EUCAST guidelines. Genetic detection of plasmid-mediated colistin resistance was performed by PCR. The faecal carriage with intrinsic colistin-resistant isolates was high (23 %), while the faecal carriage with Gram-negative rods showing acquired resistance was low (1.4 %). No isolate carried the plasmid-mediated mcr-1/mcr-2 genes. It was noteworthy that none of the patients carrying isolates with acquired colistin resistance had previously received a colistin-based treatment, while these isolates were not multidrug resistant.< Réduire

Mots clés en anglais

Anti-Bacterial Agents

Carrier State

Colistin

Drug Resistance

Bacterial

Feces

France

Gram-Negative Bacteria

Gram-Negative Bacterial Infections

Hospitals

University

Humans

Microbial Sensitivity Tests

Polymerase Chain Reaction

Prevalence