A Small Viral PPxY Peptide Motif To Control Antiviral Autophagy.
Language
EN
Article de revue
This item was published in
Journal of Virology. 2017-09-15, vol. 91, n° 18
English Abstract
Autophagy is an essential metabolic program that is also used for clearing intracellular pathogens. This mechanism, also termed selective autophagy, is well characterized for invasive bacteria but remains poorly documented ...Read more >
Autophagy is an essential metabolic program that is also used for clearing intracellular pathogens. This mechanism, also termed selective autophagy, is well characterized for invasive bacteria but remains poorly documented for viral infections. Here we highlight our recent work showing that endosomolytic adenoviruses trigger autophagy when entering cells. Our study revealed how adenoviruses exploit a capsid-associated small PPxY peptide motif to manipulate the autophagic machinery to prevent autophagic degradation and to promote endosomal escape and nuclear trafficking.Read less <
English Keywords
Adenoviridae
Autophagy
Host-Pathogen Interactions
Immune Evasion
Peptides