A Small Viral PPxY Peptide Motif To Control Antiviral Autophagy.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | MONTESPAN, Charlotte | |
| dc.contributor.author | WIETHOFF, Christopher M | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | WODRICH, Harald | |
| dc.date.accessioned | 2023-11-13T14:12:41Z | |
| dc.date.available | 2023-11-13T14:12:41Z | |
| dc.date.issued | 2017-09-15 | |
| dc.identifier.issn | 1098-5514 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184741 | |
| dc.description.abstractEn | Autophagy is an essential metabolic program that is also used for clearing intracellular pathogens. This mechanism, also termed selective autophagy, is well characterized for invasive bacteria but remains poorly documented for viral infections. Here we highlight our recent work showing that endosomolytic adenoviruses trigger autophagy when entering cells. Our study revealed how adenoviruses exploit a capsid-associated small PPxY peptide motif to manipulate the autophagic machinery to prevent autophagic degradation and to promote endosomal escape and nuclear trafficking. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Adenoviridae | |
| dc.subject.en | Autophagy | |
| dc.subject.en | Host-Pathogen Interactions | |
| dc.subject.en | Immune Evasion | |
| dc.subject.en | Peptides | |
| dc.title.en | A Small Viral PPxY Peptide Motif To Control Antiviral Autophagy. | |
| dc.title.alternative | J Virol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1128/JVI.00581-17 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 28659475 | en_US |
| bordeaux.journal | Journal of Virology | en_US |
| bordeaux.volume | 91 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 18 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04282602 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-13T14:12:43Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Virology&rft.date=2017-09-15&rft.volume=91&rft.issue=18&rft.eissn=1098-5514&rft.issn=1098-5514&rft.au=MONTESPAN,%20Charlotte&WIETHOFF,%20Christopher%20M&WODRICH,%20Harald&rft.genre=article |
