VANCAPPEL, Alexis; DANSOU, Y.; GODIN, Ophelia; HAFFEN, Emmanuel; YRONDI, Antoine; STEPHAN, Florian; RICHIERI, Raphaelle; MOLIERE, Fanny; HORN, M.; ALLAUZE, E.; GENTY, J. B.; BOUVARD, Alexandra; DOREY, J. M.; MEYREL, M.; CAMUS, V.; FOND, G.; PERAN, B.; WALTER, M.; ANGUILL, L.; SCOTTO D'APOLLONIA, C.; NGUON, A. S.; FREDEMBACH, B.; HOLTZMANN, J.; VILA, E.; PETRUCCI, J.; REY, R.; ETAIN, B.; CARMINATI, M.; COURTET, P.; VAIVA, G.; LLORCA, P. M.; LEBOYER, M.; AOUIZERATE, Bruno; BENNABI, D.; EL-HAGE, W.

doi:10.1016/j.jadr.2021.100272

VANCAPPEL, Alexis
Imaging, Brain & Neuropsychiatry [iBraiN]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Fondation FondaMental [Créteil]

DANSOU, Y.

GODIN, Ophelia
IMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]

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Article de revue

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Journal of Affective Disorders Reports. 2021-12-01, vol. 6, p. 100272

Résumé en anglais

Introduction Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample sizes. Here, we aimed to characterize cognitive impairments in TRD, and their association with the severity of depression and daily functioning. Method We included 288 patients suffering from TRD (178 women, 52.5 ± 13.1 years old). They undertook sociodemographic, clinical, daily functioning and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16). We compared our patients’ performances to theoretical performances of the general population. Results TRD was associated with poorer neuropsychological performances, except for similarities task. We found an effect of depression severity on processing speed and memory, and an impact on daily functioning affecting memory, selective attention and executive function. Conclusion Patients suffering from TRD have significant cognitive impairments. Therapeutic interventions should be developed to manage such impairments.< Réduire

Mots clés en anglais

Cognitive impairments

Executive function

Memory

Neuropsychology

Processing speed

Treatment resistant depression

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https://oskar-bordeaux.fr/handle/20.500.12278/182538

DOI

http://dx.doi.org/10.1016/j.jadr.2021.100272

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)

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Résumé en anglais

Mots clés en anglais

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