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Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)

dc.rights.licenseopenen_US
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
hal.structure.identifierCentre Hospitalier Régional Universitaire de Tours [CHRU Tours]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorVANCAPPEL, Alexis
dc.contributor.authorDANSOU, Y.
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierToulouse NeuroImaging Center [ToNIC]
hal.structure.identifierService Psychiatrie et psychologie médicale [CHU Toulouse]
dc.contributor.authorYRONDI, Antoine
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSTEPHAN, Florian
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorRICHIERI, Raphaelle
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMOLIERE, Fanny
dc.contributor.authorHORN, M.
dc.contributor.authorALLAUZE, E.
dc.contributor.authorGENTY, J. B.
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUVARD, Alexandra
dc.contributor.authorDOREY, J. M.
dc.contributor.authorMEYREL, M.
dc.contributor.authorCAMUS, V.
dc.contributor.authorFOND, G.
dc.contributor.authorPERAN, B.
dc.contributor.authorWALTER, M.
dc.contributor.authorANGUILL, L.
dc.contributor.authorSCOTTO D'APOLLONIA, C.
dc.contributor.authorNGUON, A. S.
dc.contributor.authorFREDEMBACH, B.
dc.contributor.authorHOLTZMANN, J.
dc.contributor.authorVILA, E.
dc.contributor.authorPETRUCCI, J.
dc.contributor.authorREY, R.
dc.contributor.authorETAIN, B.
dc.contributor.authorCARMINATI, M.
dc.contributor.authorCOURTET, P.
dc.contributor.authorVAIVA, G.
dc.contributor.authorLLORCA, P. M.
dc.contributor.authorLEBOYER, M.
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
IDREF: 069471851
dc.contributor.authorBENNABI, D.
dc.contributor.authorEL-HAGE, W.
dc.date.accessioned2023-06-08T12:36:34Z
dc.date.available2023-06-08T12:36:34Z
dc.date.issued2021-12-01
dc.identifier.issn2666-9153en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182538
dc.description.abstractEnIntroduction Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample sizes. Here, we aimed to characterize cognitive impairments in TRD, and their association with the severity of depression and daily functioning. Method We included 288 patients suffering from TRD (178 women, 52.5 ± 13.1 years old). They undertook sociodemographic, clinical, daily functioning and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16). We compared our patients’ performances to theoretical performances of the general population. Results TRD was associated with poorer neuropsychological performances, except for similarities task. We found an effect of depression severity on processing speed and memory, and an impact on daily functioning affecting memory, selective attention and executive function. Conclusion Patients suffering from TRD have significant cognitive impairments. Therapeutic interventions should be developed to manage such impairments.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enCognitive impairments
dc.subject.enExecutive function
dc.subject.enMemory
dc.subject.enNeuropsychology
dc.subject.enProcessing speed
dc.subject.enTreatment resistant depression
dc.title.enCognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
dc.title.alternativeJournal of Affective Disorders Reportsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jadr.2021.100272en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalJournal of Affective Disorders Reportsen_US
bordeaux.page100272en_US
bordeaux.volume6en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
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