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Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
VANCAPPEL, Alexis
Imaging, Brain & Neuropsychiatry [iBraiN]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Fondation FondaMental [Créteil]
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Imaging, Brain & Neuropsychiatry [iBraiN]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Fondation FondaMental [Créteil]
VANCAPPEL, Alexis
Imaging, Brain & Neuropsychiatry [iBraiN]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Fondation FondaMental [Créteil]
Imaging, Brain & Neuropsychiatry [iBraiN]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Fondation FondaMental [Créteil]
YRONDI, Antoine
Fondation FondaMental [Créteil]
Toulouse NeuroImaging Center [ToNIC]
Service Psychiatrie et psychologie médicale [CHU Toulouse]
Fondation FondaMental [Créteil]
Toulouse NeuroImaging Center [ToNIC]
Service Psychiatrie et psychologie médicale [CHU Toulouse]
BOUVARD, Alexandra
Centre hospitalier Charles Perrens [Bordeaux]
Fondation FondaMental [Créteil]
Nutrition et Neurobiologie intégrée [NutriNeuro]
< Reduce
Centre hospitalier Charles Perrens [Bordeaux]
Fondation FondaMental [Créteil]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Language
EN
Article de revue
This item was published in
Journal of Affective Disorders Reports. 2021-12-01, vol. 6, p. 100272
English Abstract
Introduction Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample ...Read more >
Introduction Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample sizes. Here, we aimed to characterize cognitive impairments in TRD, and their association with the severity of depression and daily functioning. Method We included 288 patients suffering from TRD (178 women, 52.5 ± 13.1 years old). They undertook sociodemographic, clinical, daily functioning and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16). We compared our patients’ performances to theoretical performances of the general population. Results TRD was associated with poorer neuropsychological performances, except for similarities task. We found an effect of depression severity on processing speed and memory, and an impact on daily functioning affecting memory, selective attention and executive function. Conclusion Patients suffering from TRD have significant cognitive impairments. Therapeutic interventions should be developed to manage such impairments.Read less <
English Keywords
Cognitive impairments
Executive function
Memory
Neuropsychology
Processing speed
Treatment resistant depression