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Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
Language
EN
Article de revue
This item was published in
Metabolism Open. 2022-09-01, vol. 15, p. 100202
English Abstract
Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological ...Read more >
Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological actors involved in such impairments. Many levels of the brain function (structure, volume, neurogenesis, neurotransmission, behavior) are involved. In this review, we detailed the part potentially played by the Hypothalamic-Pituitary Adrenal axis in these dysfunctions. Notably, regulating glucocorticoid levels, their receptors and their bioavailability appear to be relevant for future research studies, and treatment development.Read less <
English Keywords
Glucocorticoids
Hippocampus
HPA axis
Memory
Type 1 diabetes
Type 2 diabetes