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Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
Idioma
EN
Article de revue
Este ítem está publicado en
Metabolism Open. 2022-09-01, vol. 15, p. 100202
Resumen en inglés
Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological ...Leer más >
Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological actors involved in such impairments. Many levels of the brain function (structure, volume, neurogenesis, neurotransmission, behavior) are involved. In this review, we detailed the part potentially played by the Hypothalamic-Pituitary Adrenal axis in these dysfunctions. Notably, regulating glucocorticoid levels, their receptors and their bioavailability appear to be relevant for future research studies, and treatment development.< Leer menos
Palabras clave en inglés
Glucocorticoids
Hippocampus
HPA axis
Memory
Type 1 diabetes
Type 2 diabetes
Centros de investigación