The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
METTLING, Clément
Institut de génétique humaine [IGH]
Institut des Sciences de l'Evolution de Montpellier [UMR ISEM]
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Institut de génétique humaine [IGH]
Institut des Sciences de l'Evolution de Montpellier [UMR ISEM]
METTLING, Clément
Institut de génétique humaine [IGH]
Institut des Sciences de l'Evolution de Montpellier [UMR ISEM]
< Reduce
Institut de génétique humaine [IGH]
Institut des Sciences de l'Evolution de Montpellier [UMR ISEM]
Language
en
Article de revue
This item was published in
Scientific Reports. 2023, vol. 13, n° 1, p. 622
Nature Publishing Group
English Abstract
It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS ...Read more >
It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.Read less <
English Keywords
Local adaptation
dopamine receptor
population genetics
economic games
behaviour
Local adaptation
ANR Project
Idex Paris-Saclay - ANR-11-IDEX-0003
Réguler l'économie au service de la société
Réguler l'économie au service de la société
Origin
Hal imported