CLOCHARD, Gwen-Jirō; MBENGUE, Aby; METTLING, Clément; DIOUF, Birane; FAURIE, Charlotte; SENE, Omar; CHANCEREL, Emilie; GUICHOUX, Erwan; HOLLARD, Guillaume; RAYMOND, Michel; WILLINGER, Marc

doi:10.1038/s41598-022-27002-3

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CLOCHARD, Gwen-Jirō
Centre de Recherche en Économie et Statistique [CREST]
University of Chicago

MBENGUE, Aby
Université Gaston Berger de Saint-Louis Sénégal [UGB]

METTLING, Clément
Institut de génétique humaine [IGH]
Institut des Sciences de l'Evolution de Montpellier [UMR ISEM]

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Scientific Reports. 2023, vol. 13, n° 1, p. 622

Nature Publishing Group

Resumen en inglés

It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.< Leer menos

Palabras clave en inglés

Local adaptation

dopamine receptor

population genetics

economic games

behaviour

Local adaptation

DOI

http://dx.doi.org/10.1038/s41598-022-27002-3

Proyecto ANR

Idex Paris-Saclay - ANR-11-IDEX-0003
Réguler l'économie au service de la société

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BioGeCo (Biodiversité Gènes & Communautés) - UMR 1202