RAHMAN, Mujeeb Ur; BILAL, Muhammad; SHAH, Junaid Ali; KAUSHIK, Ajeet; TEISSEDRE, Pierre-Louis; KUJAWSKA, Małgorzata

doi:10.3390/pharmaceutics14061252

Langue

Article de revue

Ce document a été publié dans

Pharmaceutics. 2022-06-13, vol. 14, n° 6, p. 1252

Résumé en anglais

Parkinson’s disease (PD) and other chronic and debilitating neurodegenerative diseases (NDs) impose a substantial medical, emotional, and financial burden on individuals and society. The origin of PD is unknown due to a complex combination of hereditary and environmental risk factors. However, over the last several decades, a significant amount of available data from clinical and experimental studies has implicated neuroinflammation, oxidative stress, dysregulated protein degradation, and mitochondrial dysfunction as the primary causes of PD neurodegeneration. The new gene-editing techniques hold great promise for research and therapy of NDs, such as PD, for which there are currently no effective disease-modifying treatments. As a result, gene therapy may offer new treatment options, transforming our ability to treat this disease. We present a detailed overview of novel gene-editing delivery vehicles, which is essential for their successful implementation in both cutting-edge research and prospective therapeutics. Moreover, we review the most recent advancements in CRISPR-based applications and gene therapies for a better understanding of treating PD. We explore the benefits and drawbacks of using them for a range of gene-editing applications in the brain, emphasizing some fascinating possibilities.< Réduire

Mots clés en anglais

Parkinson’s

CRISPR-Cas9

gene therapy

delivery

applications

URI

https://oskar-bordeaux.fr/handle/20.500.12278/172322

DOI

http://dx.doi.org/10.3390/pharmaceutics14061252

Unités de recherche

Oenologie - UMR 1366

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

CRISPR-Cas9-Based Technology and Its Relevance to Gene Editing in Parkinson’s Disease

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche