Background: Overweight and obesity are associated with depression and well-being. Some psychological characteristics play a role in explaining well-being and depression in obesity and in identifying specific patient profiles. However, subtyping individuals with overweight/obesity based on variables like self-esteem or stress has not often been done. Therefore, our objective was to explore the psychological profiles of treatment-seeking individuals overweight or with obesity and to compare their depression and well-being. Methods: Data regarding eating self-efficacy, well-being, depression, physical hunger, self-esteem, body satisfaction and perceived stress in individuals with overweight/obesity were collected from the ESTEAM cohort. Hierarchical cluster analysis and mean comparisons were performed on female (n = 1427) and male samples (n = 310). Results: Three psychological profiles were identified in both samples. The “High psychological concerns” profile and the “Low psychological concerns” profile were identical in both samples. The third profile, “Bodily concerns”, differed by sex and was characterized by appearance dissatisfaction for women and by appearance and eating concerns for men. The ”Low psychological concerns” profile presented the highest well-being and the lowest depression scores in both samples. Discussion: The findings support the hypothesis of the heterogeneity of individuals with overweight and obesity and suggest sex-related therapeutic approaches.Read less <