MOISAN, Marie  Pierre

doi:10.1016/j.coemr.2022.100418

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MOISAN, Marie Pierre

Nutrition et Neurobiologie intégrée [NutriNeuro]

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Article de revue

Ce document a été publié dans

Current Opinion in Endocrine and Metabolic Research. 2022-12, vol. 27

Résumé en anglais

Recent studies have revealed that adolescence is a period of intense brain plasticity rendering this developmental stage vulnerable to the deleterious effects of stress on mental health. Stress-sensitive brain regions, involved in cognitive and affective processes, are actively developing during this period, through synaptic pruning, myelination, and connectivity between each other. Specific stress reactivity in adolescence may result from the programming effect of previous early life adversities or from exposure to stressors incurred during the peri-adolescent period. In each case, the outcomes are often sex-specific due to difference in genes present on sex chromosomes, sex-specific parent-of-origin gene expression as well as the influence of gonadal hormones that impact brain maturation during development and around puberty. Misreporting of sex dimorphism still exist and need to be solved by better training. More longitudinal clinical analyses are awaited to separate the effect of cumulative stress to the ones occurring specifically at adolescence. © 2022 Elsevier Ltd< Réduire

Mots clés en anglais

Glucocorticoids

Adversity

Synaptic pruning

Myelin

Gender

Puberty

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170514

DOI

http://dx.doi.org/10.1016/j.coemr.2022.100418

Project ANR

Mémoire des Adolescents Obeses: Influences des Rythmes circadiens - ANR-21-CE14-0086

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286