EBERLEIN, Chris; ABOU SAADA, Omar; FRIEDRICH, Anne; ALBERTIN, Warren; SCHACHERER, Joseph

doi:10.1101/gr.275380.121

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Article de revue

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Genome Research. 2021-11-23

Résumé en anglais

Polyploidization events are observed across the tree of life and occur in many fungi, plant, and animal species. During evolution, polyploidy is thought to be an important source of speciation and tumorigenesis. However, the origin of polyploid populations is not always clear, and little is known about the precise nature and structure of their complex genome. Using a long-read sequencing strategy, we sequenced 71 strains from the yeast species, which is found in anthropized environments (e.g., beer, contaminant of wine, kombucha, and ethanol production) and characterized by several polyploid subpopulations. To reconstruct the polyploid genomes, we phased them by using different strategies and found that each subpopulation had a unique polyploidization history with distinct trajectories. The polyploid genomes contain either genetically closely related (with a genetic divergence 3%), indicating auto- as well as allopolyploidization events. These latest events have occurred independently with a specific and unique donor in each of the polyploid subpopulations and exclude the known sister species as possible donors. Finally, loss of heterozygosity events has shaped the structure of these polyploid genomes and underline their dynamics. Overall, our study highlights the multiplicity of the trajectories leading to polyploid genomes within the same species.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140206

DOI

http://dx.doi.org/10.1101/gr.275380.121

Lien vers les données de la recherche

https://www.genome.org/cgi/doi/10.1101/gr.275380.121.

Project ANR

Par-delà les frontières, l'Université de Strasbourg - ANR-10-IDEX-0002
Façonner les talents en formation et en recherche à l'Université de Strasbourg - ANR-20-SFRI-0012
Integrative Molecular and Cellular Biology - ANR-17-EURE-0023
Approche multi-échelle de l'adaptation de la levure Brettanomyces bruxellensis aux procédés fermentaires - ANR-18-CE20-0003
Evolution du patron de recombinaison et de mutations fonctionnelles à travers différentes espèces

Unités de recherche

Oenologie - UMR 1366

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Different trajectories of polyploidization shape the genomic landscape of the Brettanomyces bruxellensis yeast species