Alzheimer's disease and Helicobacter pylori infection: inflammation from stomach to brain?
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EN
Article de revue
Ce document a été publié dans
Journal of Alzheimer's Disease. 2020, vol. 73, n° 2, p. 801-809
Résumé en anglais
Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the ...Lire la suite >
Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylon-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n= 15) or Helicobacter felis (n= 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis>H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.< Réduire
Mots clés en anglais
Alzheimer's disease
dementia
gastric inflammation
GFAP
Helicobacter infection
iba-1
neuroinflammation
Unités de recherche