ALBARET, Guillaume; SIFRE, Elodie; FLOCH, Pauline; LAYE, Sophie; AUBERT, Agnes; DUBUS, Pierre; AZZI-MARTIN, Lamia; GIESE, Alban; SALLES, Nathalie; MEGRAUD, Francis; VARON, Christine; LEHOURS, Philippe; ROUBAUD-BAUDRON, Claire

doi:10.3233/JAD-190496

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ALBARET, Guillaume
Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn]

SIFRE, Elodie
Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn]

FLOCH, Pauline
Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn]

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Journal of Alzheimer's Disease. 2020, vol. 73, n° 2, p. 801-809

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Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylon-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n= 15) or Helicobacter felis (n= 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis>H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.< Leer menos

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Alzheimer's disease

dementia

gastric inflammation

GFAP

Helicobacter infection

iba-1

neuroinflammation

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Alzheimer's disease and Helicobacter pylori infection: inflammation from stomach to brain?

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