Alzheimer's disease and Helicobacter pylori infection: inflammation from stomach to brain?
Language
EN
Article de revue
This item was published in
Journal of Alzheimer's Disease. 2020, vol. 73, n° 2, p. 801-809
English Abstract
Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the ...Read more >
Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylon-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n= 15) or Helicobacter felis (n= 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis>H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.Read less <
English Keywords
Alzheimer's disease
dementia
gastric inflammation
GFAP
Helicobacter infection
iba-1
neuroinflammation