Microglia in neuronal plasticity: Influence of stress
Language
EN
Article de revue
This item was published in
Neuropharmacology. 2015-09, vol. 96, n° Pt A, p. 19-28
English Abstract
The central nervous system (CNS) has previously been regarded as an immune-privileged site with the absence of immune cell responses but this dogma was not entirely true. Microglia are the brain innate immune cells and ...Read more >
The central nervous system (CNS) has previously been regarded as an immune-privileged site with the absence of immune cell responses but this dogma was not entirely true. Microglia are the brain innate immune cells and recent findings indicate that they participate both in CNS disease and infection as well as facilitate normal CNS function. Microglia are highly plastic and play integral roles in sculpting the structure of the CNS, refining neuronal circuitry and connectivity, and contribute actively to neuronal plasticity in the healthy brain. Interestingly, psychological stress can perturb the function of microglia in association with an impaired neuronal plasticity and the development of emotional behavior alterations. As a result it seemed important to describe in this review some findings indicating that the stress-induced microglia dysfunction may underlie neuroplasticity deficits associated to many mood disorders. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'.Read less <
English Keywords
Animals
Brain
Catecholamine
Cell Communication
Cognition Disorders
Corticosterone
Cytokine
Humans
Microglia
Mood Disorders
Neuronal Plasticity
Neurons
Neuroplasticity
Stress
Stress
Psychological
Synapse