DELPECH, Jean-Christophe; MADORE, Charlotte; NADJAR, Agnes; JOFFRE, Corinne; WOHLEB, Eric S.; LAYE, Sophie

doi:10.1016/j.neuropharm.2014.12.034

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DELPECH, Jean-Christophe
Nutrition et Neurobiologie intégrée [NutriNeuro]

MADORE, Charlotte
Nutrition et Neurobiologie intégrée [NutriNeuro]

NADJAR, Agnes

Nutrition et Neurobiologie intégrée [NutriNeuro]

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Neuropharmacology. 2015-09, vol. 96, n° Pt A, p. 19-28

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The central nervous system (CNS) has previously been regarded as an immune-privileged site with the absence of immune cell responses but this dogma was not entirely true. Microglia are the brain innate immune cells and recent findings indicate that they participate both in CNS disease and infection as well as facilitate normal CNS function. Microglia are highly plastic and play integral roles in sculpting the structure of the CNS, refining neuronal circuitry and connectivity, and contribute actively to neuronal plasticity in the healthy brain. Interestingly, psychological stress can perturb the function of microglia in association with an impaired neuronal plasticity and the development of emotional behavior alterations. As a result it seemed important to describe in this review some findings indicating that the stress-induced microglia dysfunction may underlie neuroplasticity deficits associated to many mood disorders. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'.< Leer menos

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Animals

Brain

Catecholamine

Cell Communication

Cognition Disorders

Corticosterone

Cytokine

Humans

Microglia

Mood Disorders

Neuronal Plasticity

Neurons

Neuroplasticity

Stress

Psychological

Synapse

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Microglia in neuronal plasticity: Influence of stress

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